Synthesis of chiral sulfoximine-based thioureas and their application in asymmetric organocatalysis
نویسندگان
چکیده
For the first time, chiral sulfoximine derivatives have been applied as asymmetric organocatalysts. In combination with a thiourea-type backbone the sulfonimidoyl moiety leads to organocatalysts showing good reactivity in the catalytic desymmetrization of a cyclic meso-anhydride and moderate enantioselectivity in the catalytic asymmetric Biginelli reaction. Straightforward synthetic routes provide the newly designed thiourea-sulfoximine catalysts in high overall yields without affecting the stereohomogeneity of the sulfur-containing core fragment.
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عنوان ژورنال:
دوره 8 شماره
صفحات -
تاریخ انتشار 2012